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Billionaire Mark Cuban’s Cost Plus Drugs will begin manufacturing its own medications this week

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The Mark Cuban Cost Plus Drug Company will begin manufacturing its own medications in Texas this week, cofounder and CEO Dr. Alex Oshmyansky announced Monday during a White House roundtable on lowering health care costs.

“Cost Plus Drugs is proudly bringing pharmaceutical manufacturing back to the U.S., with advanced robotic and AI computer vision technology,” Oshmyansky said. “That allows us to pivot from making one drug type to another very rapidly—in principle, within four hours. 

“That way, whatever product is in shortage, we can start making that product.”

The company, which Oshmyansky launched in January 2022 alongside billionaire entrepreneur Mark Cuban, will first manufacture commercial batches of epinephrine, which is used in EpiPens, and norepinephrine, which is used to increase and maintain blood pressure, for hospital patients in intensive care. Oshmyansky didn’t mention specific dates, only that production of these two drugs would begin “this week,” followed “shortly after” by pediatric oncology drugs.

“No parent should be told the chemotherapy their child needs is not available,” Oshmyansky said. “Nobody should not get the life-saving ICU medications they need or have to postpone their surgery because the common chief medications are just not available in the United States in the year 2024.”

Cost Plus Drugs’ 22,000-square-foot pharmaceutical facility in Dallas’ Deep Ellum neighborhood originally had been slated for completion in late 2022. Just as important as the drugs themselves is the way in which they’re produced, Oshmyansky said: without middlemen. 

Pills decorated with dollar billsPills decorated with dollar bills
The Mark Cuban Cost Plus Drug Company is grounded in the simplicity of buying drugs and selling them directly to consumers at low, transparent costs, Cuban said during a White House roundtable Monday, March 4, 2024.

GP Kidd—Getty Images

White House roundtable talks pharmaceutical middlemen

The subject of intermediary pharmacy benefit managers, or PBMs, dominated discussion during the White House roundtable Monday afternoon. Cuban was also in attendance, along with public and private leaders including Democratic Kentucky Gov. Andy Beshear and Sandra Clarke, COO of Blue Shield of California.

PBMs, Cuban said, have been “shitting on independent pharmacies,” among other tactics that take advantage of the most vulnerable patients and “put stock prices over health.” 

Cost Plus Drugs is grounded in the simplicity of buying drugs and selling them directly to consumers at low, transparent costs, Cuban stressed. The online retailer now carries 2,500 medications and plans to offer as many as legally possible.

PBMs work with pharmaceutical wholesalers to set up so-called source programs, which control 90% of drug purchasing in the U.S., Oshmyansky explained, noting Cost Plus Drugs will be as open about its manufacturing costs as it is about the prescriptions it currently sells.

“That way, we are profitable and sustainable,” Oshmyansky said, “but never extortionate.”

For more on the Mark Cuban Cost Plus Drug Company:

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China’s EV makers are having more trouble paying their bills and now take 2 to 3 times longer than Tesla does

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The time it’s taking for some of China’s electric-car makers to pay suppliers is ballooning — a further sign of stress in the nation’s increasingly cutthroat auto market.

Nio Inc. was taking around 295 days to clear its receipts payable, the vast majority of which are owed to suppliers, at the end of 2023 versus 197 days in 2021, according to the most recent available data compiled by Bloomberg. Xpeng Inc., another US-listed Chinese EV maker, was taking 221 days to honor its obligations to vendors and related parties, up from 179 days, the data show.

Elon Musk’s Tesla Inc., by comparison, only took around 101 days, and that period has remained largely stable in the past three years.

The extended payment cycles are indicative of the pressure many automakers are under in China, where economic growth remains sluggish and consumer sentiment is subdued. That’s translated into reduced demand for electric cars, and the once fast-growing market is now beset with intense price wars and crunched profit margins.

Since Beijing phased out a national subsidy program for EV purchases in 2022, some smaller manufacturers have been pushed to the brink. WM Motors filed for restructuring in October, and Human Horizons Group Inc., the owner of premium EV brand HiPhi, suspended operations for at least six months in February.

“Everybody’s suffering,” said Jochen Siebert, managing director at consultancy JSC Automotive. “For manufacturers, price reductions mean less money coming in. So the money they owe to their suppliers may be necessary for them to remain liquid.”

Representatives for Nio and Xpeng didn’t respond to requests for comment.

Delayed payments are starting to have a knock-on effects at auto-parts suppliers, Siebert said.

“Tier-three or four suppliers really get bitten, because they can’t pass it on,” he said, adding the EV sector may see a “messy consolidation” as suppliers go bankrupt, quickly causing production issues for automakers down the line.

Indeed Jiaxing, Zhejiang-based Minth Group Ltd., a supplier of exterior body parts, saw its accounts and notes receivables surge more than 40% to 4.74 billion yuan ($656 million) as of December from the end of 2020, while its cash and equivalents shrank by almost one-third to 4.2 billion yuan over the same period, according to data compiled by Bloomberg.

Hunan Yuneng New Energy Battery Material Co., which is a major supplier to BYD Co., according to data compiled by Bloomberg, saw its accounts and notes receivables more than triple to 10.43 billion yuan at the end of 2022 from a year earlier, while cash reserves fell to 435.2 million yuan.

“The price war won’t end soon and the stress eventually will be delivered to suppliers,” said Zhu Lin, a Shanghai-based managing director with turnaround management firm Alvarez & Marsal.

“We’ve seen more car components producers approaching us to improve their performance and some of them are thinking about offloading unprofitable businesses,” Zhu said. “The weak ones in the supply chain will face a high risk of being kicked out of the game.”

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Russian strikes on Ukraine’s Kharkiv region kill at least 11

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A view shows a crater that appeared after a Russian missile strike on a structure at a resort, amid Russia’s attack on Ukraine, in Kharkiv, Ukraine May 19, 2024. REUTERS/Valentyn Ogirenko

Valentyn Ogirenko | Reuters

Russia struck a busy lakeside resort on the edge of Ukraine’s second largest city on Sunday and also attacked villages in the surrounding region, killing at least 11 people and wounding scores.

The missile strikes were the latest in what have been constant Russian attacks in recent weeks on the Kharkiv region of northeastern Ukraine, where Russian troops have launched an offensive.

Valentyna, 69, had blood running down her face at the lakeside resort area where her home had been destroyed and a busy restaurant nearby been obliterated. Her husband was killed down by the water, she said, gesturing to the area near the shore where there was now a crater, rubble and corpses.

“To lose my husband, to lose my house, to lose everything in the world, it hurts, it hurts me,” she shouted through tears “They (the Russians) are animals, why do they need to kill people?”

Prosecutors said six people were killed there, one was still missing and 27 wounded. Rescuers said the initial strike was followed by a second strike around 20 minutes later, targeting emergency crews at the scene in a so-called “double tap”.

“There were never any soldiers here,” said Yaroslav Trofimko, a police inspector who arrived after the first strike and was then caught up in the second. “It was a Sunday, people were supposed to be here to rest, children were supposed to he here, pregnant women, resting, enjoying a normal way of life.”

Another five people were killed and 9 injured later in the day in two villages in Kupiansk district. Local governor Oleh Syniehubov said Russian forces shelled two villages of the district with a self-propelled multiple rocket launcher.

President Volodymyr Zelenskyy again called on Western allies to supply Kyiv with additional air defence systems to protect Kharkiv and other cities.

“The world can stop Russian terror – and to do so, the lack of political will among leaders must be overcome,” Zelenskyy said on Telegram.

“Two Patriots for Kharkiv will make a fundamental difference,” he said, referring to Patriot missile defence systems. Air defence systems for other cities and sufficient support for soldiers on the front line would ensure Russia’s defeat, the president added



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Leading business figure Sir Anthony O'Reilly dies

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He built an international media business which at one stage owned more than 100 newspapers.



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